Idiopathic pulmonary fibrosis in infants
Identifieur interne : 000407 ( France/Analysis ); précédent : 000406; suivant : 000408Idiopathic pulmonary fibrosis in infants
Auteurs : Eric Osika [France] ; Marie-Helene Muller [France] ; Liliane Boccon-Gibod [France] ; Brigitte Fauroux [France] ; Anne Sardet [France] ; Cecile Grosskopf [France] ; Jacques Couvreur [France] ; Guy Tournier [France] ; Annick Clement [France]Source :
- Pediatric Pulmonology [ 8755-6863 ] ; 1997-01.
Descripteurs français
- KwdFr :
- MESH :
- diagnostic : Fibrose pulmonaire.
- usage thérapeutique : Glucocorticoïdes.
- Biopsie, Bronchoscopie, Femelle, Fibrose pulmonaire, Humains, Issue fatale, Lavage bronchoalvéolaire, Mâle, Nourrisson, Oxygénothérapie.
English descriptors
- KwdEn :
- MESH :
- chemical , therapeutic use : Glucocorticoids.
- diagnosis : Pulmonary Fibrosis.
- therapy : Pulmonary Fibrosis.
- Biopsy, Bronchoalveolar Lavage, Bronchoscopy, Fatal Outcome, Female, Humans, Infant, Male, Oxygen Inhalation Therapy.
Abstract
Idiopathic pulmonary fibrosis is a poorly characterized disease in infants. In the present report, we reviewed our experience with 10 infants during a 10‐year period. In 9 patients, onset of symptoms occurred before the age of 2 months and included tachypnea, cough, and inadequate weight gain. However, despite the presence of these symptoms, diagnosis was delayed for 3 months at which time the infants were referred to the pediatric pulmonary department, when the diagnosis was confirmed by open lung biopsy. At the time of admission, bronchoscopy with alveolar lavage was performed in 9 children and showed severe alveolitis with an increase in the neutrophil count. Nine infants were treated with prednisone alone or in combination with chloroquine, colchicine, or cyclophosphamide; all these patients died despite treatment. One infant was treated with pulses of methylprednisolone because of a failure in response to oral prednisone. This girl who displayed similar clinical, radiological, and histological abnormalities as the other children at the time of diagnosis is the only child still alive after 3 years of follow‐up. She is now free of respiratory symptoms and has a normal growth curve. The present report raised two important points: (1) a thorough evaluation of characteristic symptoms should lead to an early diagnosis of pulmonary fibrosis in infants; and (2) administration of pulse therapy using corticosteroids has been helpful and needs to be evaluated further. Pediatr Pulmonol. 1997; 23:49–54. © 1997 Wiley‐Liss, Inc.
Url:
DOI: 10.1002/(SICI)1099-0496(199701)23:1<49::AID-PPUL6>3.0.CO;2-K
Affiliations:
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to="54">54</biblScope><biblScope unit="page-count">6</biblScope><publisher>John Wiley & Sons, Inc.</publisher><pubPlace>New York</pubPlace><date type="published" when="1997-01">1997-01</date></imprint><idno type="ISSN">8755-6863</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">8755-6863</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Biopsy</term><term>Bronchoalveolar Lavage</term><term>Bronchoscopy</term><term>Fatal Outcome</term><term>Female</term><term>Glucocorticoids (therapeutic use)</term><term>Humans</term><term>Infant</term><term>Male</term><term>Oxygen Inhalation Therapy</term><term>Pulmonary Fibrosis (diagnosis)</term><term>Pulmonary Fibrosis (therapy)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Biopsie</term><term>Bronchoscopie</term><term>Femelle</term><term>Fibrose pulmonaire ()</term><term>Fibrose pulmonaire (diagnostic)</term><term>Glucocorticoïdes (usage thérapeutique)</term><term>Humains</term><term>Issue fatale</term><term>Lavage bronchoalvéolaire</term><term>Mâle</term><term>Nourrisson</term><term>Oxygénothérapie</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Glucocorticoids</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Pulmonary Fibrosis</term></keywords><keywords scheme="MESH" qualifier="diagnostic" xml:lang="fr"><term>Fibrose pulmonaire</term></keywords><keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Pulmonary Fibrosis</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Glucocorticoïdes</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Biopsy</term><term>Bronchoalveolar Lavage</term><term>Bronchoscopy</term><term>Fatal Outcome</term><term>Female</term><term>Humans</term><term>Infant</term><term>Male</term><term>Oxygen Inhalation Therapy</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Biopsie</term><term>Bronchoscopie</term><term>Femelle</term><term>Fibrose pulmonaire</term><term>Humains</term><term>Issue fatale</term><term>Lavage bronchoalvéolaire</term><term>Mâle</term><term>Nourrisson</term><term>Oxygénothérapie</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Idiopathic pulmonary fibrosis is a poorly characterized disease in infants. In the present report, we reviewed our experience with 10 infants during a 10‐year period. In 9 patients, onset of symptoms occurred before the age of 2 months and included tachypnea, cough, and inadequate weight gain. However, despite the presence of these symptoms, diagnosis was delayed for 3 months at which time the infants were referred to the pediatric pulmonary department, when the diagnosis was confirmed by open lung biopsy. At the time of admission, bronchoscopy with alveolar lavage was performed in 9 children and showed severe alveolitis with an increase in the neutrophil count. Nine infants were treated with prednisone alone or in combination with chloroquine, colchicine, or cyclophosphamide; all these patients died despite treatment. One infant was treated with pulses of methylprednisolone because of a failure in response to oral prednisone. This girl who displayed similar clinical, radiological, and histological abnormalities as the other children at the time of diagnosis is the only child still alive after 3 years of follow‐up. She is now free of respiratory symptoms and has a normal growth curve. The present report raised two important points: (1) a thorough evaluation of characteristic symptoms should lead to an early diagnosis of pulmonary fibrosis in infants; and (2) administration of pulse therapy using corticosteroids has been helpful and needs to be evaluated further. Pediatr Pulmonol. 1997; 23:49–54. © 1997 Wiley‐Liss, Inc.</div></front></TEI><affiliations><list><country><li>France</li></country><region><li>Île-de-France</li></region><settlement><li>Paris</li></settlement></list><tree><country name="France"><region name="Île-de-France"><name sortKey="Osika, Eric" sort="Osika, Eric" uniqKey="Osika E" first="Eric" last="Osika">Eric Osika</name></region><name sortKey="Boccon Ibod, Liliane" sort="Boccon Ibod, Liliane" uniqKey="Boccon Ibod L" first="Liliane" last="Boccon-Gibod">Liliane Boccon-Gibod</name><name sortKey="Clement, Annick" sort="Clement, Annick" uniqKey="Clement A" first="Annick" last="Clement">Annick Clement</name><name sortKey="Clement, Annick" sort="Clement, Annick" uniqKey="Clement A" first="Annick" last="Clement">Annick Clement</name><name sortKey="Couvreur, Jacques" sort="Couvreur, Jacques" uniqKey="Couvreur J" first="Jacques" last="Couvreur">Jacques Couvreur</name><name sortKey="Fauroux, Brigitte" sort="Fauroux, Brigitte" uniqKey="Fauroux B" first="Brigitte" last="Fauroux">Brigitte Fauroux</name><name sortKey="Grosskopf, Cecile" sort="Grosskopf, Cecile" uniqKey="Grosskopf C" first="Cecile" last="Grosskopf">Cecile Grosskopf</name><name sortKey="Muller, Marie Elene" sort="Muller, Marie Elene" uniqKey="Muller M" first="Marie-Helene" last="Muller">Marie-Helene Muller</name><name sortKey="Sardet, Anne" sort="Sardet, Anne" uniqKey="Sardet A" first="Anne" last="Sardet">Anne Sardet</name><name sortKey="Tournier, Guy" sort="Tournier, Guy" uniqKey="Tournier G" first="Guy" last="Tournier">Guy Tournier</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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